WATS3D Increases Detection of Pre-Cancerous Changes in the Esophagus by Over 80%

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A newly published study says that adjunctive use of the CDx Diagnostics WATS3D tissue sampling and analysis system increases the detection of both Barrett’s esophagus and esophageal dysplasia by over 80%.

CDx Diagnostics, developer of WATS3D, or Wide Area Transepithelial Sampling with 3D Tissue Analysis for the detection and surveillance of Barrett’s esophagus, has announced results from a study published in the latest issue of United European Gastroenterology Journal. The multicenter prospective 4000 patient study also features in the American Society for Gastrointestinal Endoscopy (ASGE)’s Scope Tech Talk video series.

Gastroenterologists perform more than five million upper endoscopies each year on patients with chronic heartburn and Barrett’s esophagus in an effort to find precancerous cells before they can progress to cancer (Esophageal adenocarcinoma). A major problem with this strategy is that endoscopists had hitherto relied on taking small random forceps biopsies at 1-2 cm intervals to find these abnormal cells, leaving more than 96% of the endoscopically suspect area completely untested.

CDx Diagnostics’ WATS3D addresses the major inadequacies inherent in current random forceps biopsy testing of the esophagus. In just a few minutes, endoscopists can easily obtain a wide area, full-thickness transepithelial tissue sample for computer-assisted 3D laboratory analysis by expert pathologists. WATS3D enables doctors to rapidly collect a sample from a much larger surface area of the esophagus. The system combines a larger sampling area with patented 3D imaging and expert cytopathology. If precancerous cells are present, they can now be easily detected and removed or destroyed before they become cancerous – essentially preempting esophageal cancer.

The multicenter prospective trial was conducted at 25 community-based gastrointestinal (GI) centers across the United States. In the study, 4,203 patients were tested for esophageal disease. The findings show that with the inclusion of WATS3D overall detection of Barrett’s increased by 83%, while the detection of dysplasia increased by 88%. The study concludes that the sampling error can be improved dramatically with use of this adjunctive technique.

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